An androgen produced mainly by the adrenal glands.
Why it matters for PCOS
DHEA-S (dehydroepiandrosterone sulfate) comes almost entirely from the adrenal glands rather than the ovaries, so it gives a specific picture of the adrenal contribution to androgen levels. In PCOS, doctors sometimes check DHEA-S when androgen symptoms such as acne, excess hair, or scalp hair thinning are present, to gauge whether an adrenal source is involved. It is interpreted alongside other tests such as testosterone, not on its own.
A mildly raised DHEA-S is common in some women with PCOS. A markedly high level may prompt a doctor to look for causes other than PCOS, such as an adrenal gland problem. Only a doctor can interpret the result in your context.
This glossary is education, not diagnosis. For your own situation, ask a doctor or pharmacist.